An immunologic intrigue: psoriasis vulgaris developing on pemphigus foliaceous

Coexistence of psoriasis vulgaris and pemphigus foliaceus.

Characterization of the regulatory regions in the human desmoglein genes encoding the pemphigus foliaceous and pemphigus vulgaris antigens.

The adhesive proteins in the desmosome type of cell junction consist of two members of the cadherin superfamily, the desmogleins and desmocollins. Both desmogleins and desmocollins occur as at least three different isoforms with various patterns of expression. The molecular mechanisms controlling the differential expression of the desmosomal cadherin isoforms are not yet known. We have begun an...

Pemphigus Vulgaris and Pemphigus Foliaceus

The word “pemphigus” is derived from the Greek term "pemphix” meaning bubble or blister. Pemphigus is a group of autoimmune diseases (see Table 4) characterized by intra-epithelial blistering, resulting in superficial vesicles or bullae that easily rupture, resulting in ulceration of mucosal and/or cutaneous sites. Although rare, pemphigus causes significant morbidity and potential mortality fo...

Management of Pemphigus Vulgaris

INTRODUCTION Pemphigus vulgaris (PV) is a chronic, autoimmune, vesiculobullous disease. As a result of the relative rarity of PV, published randomized controlled trials (RCTs) are limited, which makes it difficult to evaluate the efficacy of different treatment regimens in this disease. This also precludes conduct of a meta-analysis. METHODS English-language publications describing treatment ...

Juvenile Pemphigus Vulgaris

Pemphigus vulgaris (PV) is a chronic autoimmune blistering disease of the skin and mucous membranes that affects older individuals. The disease rarely affects children and adolescent patients. The first manifestation of PV appears in the oral mucosa in the majority of patients, followed by cutaneous lesions. The diagnosis is based on clinical findings and laboratory analyses, and it is usually ...